Small solutes peritoneal membrane transport and endothelial function

Influence of convection on the diffusive transport and sieving of water and small solutes across the peritoneal membrane.

The three-pore model of peritoneal membrane physiology predicts sieving of small solutes as a result of the presence of a water-exclusive pathway. The purpose of this study was to measure the diffusive and convective components of small solute transport, including water, under differing convection. Triplicate studies were performed in eight stable individuals using 2-L exchanges of bicarbonate ...

Teflon Af Membrane Transport of Organic Solutes

Peritoneal membrane transport function in children receiving long-term dialysis.

Accurate characterization of peritoneal solute transport capacity in children has been hampered by a lack of standardized test mechanics and small patient numbers. A standardized peritoneal equilibration test was used to study 95 pediatric patients (mean age, 9.9 +/- 5.6 yr) receiving chronic peritoneal dialysis at 14 centers. Patients were divided into four age groups (< 1, 1 to 3, 4 to 11, 12...

MEMBRANE INTERACTIONS OF SMALL SOLUTES Studies with drugs and osmolytes

To Sanni 5 CONTENTS ABBREVIATIONS 8 LIST OF ORIGINAL PUBLICATIONS 10 SUMMARY 11 1. REVIEW OF THE LITERATURE 13 1.1. Biological membranes 13 Structure and composition 13 Dynamics and organization 13 1.2. Lipid dynamics 15 Intra-and intermolecular dynamics 15 Lateral pressure profile 16 Lipid bilayer as a permeability barrier 17 1.3. Membrane hydration 18 1.4. Membrane lateral heterogeneity 19 1....

Water transport across the peritoneal membrane.

Peritoneal dialysis involves diffusive and convective transports and osmosis through the highly vascularized peritoneal membrane. The capillary endothelium offers the rate-limiting hindrance for solute and water transport. It can be functionally described in terms of a three-pore model including transcellular, ultrasmall pores responsible for free-water transport during crystalloid osmosis. Sev...